ALLOGENEIC MARROW OR PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR AGNOGENIC MYELOID METAPLASIA WITH MYELOFIBROSIS
busulfan
+ cyclophosphamide
+ cyclosporine
Blood Coagulation Disorders+21
+ Blood Platelet Disorders
+ Bone Marrow Diseases
Treatment Study
Summary
Study start date: June 1, 1996
Actual date on which the first participant was enrolled.OBJECTIVES: Assess disease free survival in patients with idiopathic myelofibrosis treated with a preparative busulfan/cyclophosphamide regimen followed by allogeneic bone marrow or peripheral blood stem cell transplantation. Determine the risk of primary graft failure in these patients. OUTLINE: Patients receive a preparative regimen consisting of oral busulfan every 6 hours on days -7 through -4 and cyclophosphamide on days -3 and -2. Patients then receive allogeneic bone marrow or peripheral blood stem cells on day 0. Patients registered on protocol FHCRC-1106.00 randomized to stem cell transplant receive unmodified G-CSF-mobilized stem cells from an HLA-identical donor. Patients receive cyclosporine/methotrexate or tacrolimus/methotrexate as prophylaxis for graft-versus-host disease (GVHD). Patients receiving marrow from unrelated donors are eligible for appropriate GVHD prophylaxis studies. Patients are followed at 6 and 12 months after transplant. PROJECTED ACCRUAL: A maximum of 20 patients will be accrued for this study over approximately 3.5 years.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.20 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Until 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
DISEASE CHARACTERISTICS: Idiopathic myelofibrosis (IMF) with at least 1 poor prognosis characteristic, including but not limited to: Hemoglobin less than 10 g/dL Platelet count less than 100,000/mm^3 Hepatomegaly (i.e., palpable liver edge 5 cm below costal margin) Clinical requirement for splenectomy Other myeloproliferative disorders in an IMF like myelofibrotic state eligible No evidence of leukemic progression, e.g.: Greater than 15% peripheral blood blasts Fever or bone pain of unknown origin Rapidly progressing splenomegaly No other causes for myelofibrosis, such as: Collagen vascular disorder Lymphoma Granulomatous infection Metastatic carcinoma Hairy cell leukemia Myelodysplastic syndrome No active central nervous system disease One of the following donor/patient pairings is required: Donor status: Genotypic or phenotypic HLA-matched relative Maximum patient age of 65 One antigen HLA-mismatched relative, HLA-matched unrelated donor, or one antigen HLA-mismatched unrelated donor Maximum patient age of 55 Transplant on this protocol allowed for patients registered on protocol FHCRC-1106.00 PATIENT CHARACTERISTICS: Age: 65 and under Performance status: Not specified Hematopoietic: See Disease Characteristics Hepatic: Bilirubin no greater than 2 times normal SGPT no greater than 4 times normal Renal: Creatinine no greater than two times normal OR Creatinine clearance at least 50% Cardiovascular: Ejection fraction at least 50% Cardiac evaluation required if signs or symptoms of coronary artery disease or congestive heart failure Other: HIV negative No active infection Patients excluded from this protocol are referred to protocol FHCRC-179.05 PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: Not specified
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Fred Hutchinson Cancer Research Center
Seattle, United StatesOpen Fred Hutchinson Cancer Research Center in Google Maps