Completed

Fluconazole vs. Amphotericin B: Safety, Tolerance, and Efficacy in Treating Fungal Infections

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Fluconazole

+ Amphotericin B

Drug
Who is being recruted

Blood-Borne Infections+21

+ Urogenital Diseases

+ Genital Diseases

Over 13 Years
+25 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 3
Interventional
See protocol details

Summary

Principal SponsorPfizer
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

This study focuses on comparing two medications, fluconazole and amphotericin B, for treating fungal infections. These infections can occur in major organs, spread throughout the body, or be present in the bloodstream. The study involves adult patients who have low white blood cell counts (neutropenic) or normal counts (non-neutropenic), but do not have AIDS, AIDS-related complex (ARC), or extensive burns. HIV-positive patients are included only if they also have cancer. The goal is to find a safer and more effective treatment for fungal infections in these patient populations.

NCT00002277
Principal SponsorPfizer
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 13 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Blood-Borne InfectionsUrogenital DiseasesGenital DiseasesCytopeniaAgranulocytosisBacterial Infections and MycosesCommunicable DiseasesHematologic DiseasesHemic and Lymphatic DiseasesImmunologic Deficiency SyndromesImmune System DiseasesInfectionsLeukocyte DisordersLeukopeniaRetroviridae InfectionsRNA Virus InfectionsSexually Transmitted DiseasesVirus DiseasesSexually Transmitted Diseases, ViralLentivirus InfectionsMycosesNeoplasmsNeutropeniaHIV Infections

Criteria

12 inclusion criteria required to participate
Diagnosis or presumption of fungal infection under defined conditions
Written informed consent either from the patient or the patient's legal guardian
Barbiturates
Coumarin-type anticoagulants
Show More Criteria
13 exclusion criteria prevent from participating
Burns > 30 percent of the body
Concomitant antifungal agents other than the study drugs
Diagnosis of AIDS or AIDS related complex (ARC)
Evidence of previous amphotericin B sensitivity
Show More Criteria

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 3 locations

Dr Layne Gentry

Houston, United StatesOpen Dr Layne Gentry in Google Maps

Dr Temple Williams

Houston, United States

M D Anderson Cancer Ctr

Houston, United States
Completed3 Study Centers