Completed
Magnesium Sulfate Effect on Foscarnet Therapy Symptoms and Divalent Cation Levels
What is being tested
Magnesium sulfate
+ Foscarnet sodium
Drug
Who is being recruted
Blood-Borne Infections+25
+ Urogenital Diseases
+ Genital Diseases
Over 18 Years
+11 Eligibility Criteria
How is the trial designed
Treatment Study
Phase 4
Interventional
Summary
Principal SponsorAstra USA
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner
Patients are randomized to one of four treatment groups. Intravenous foscarnet is administered for 4 days. Patients receive one of three doses of magnesium sulfate or placebo in normal saline according to one of four schedules. Sequence of doses will differ for each group.
Principal SponsorAstra USA
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
12 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Blood-Borne InfectionsUrogenital DiseasesGenital DiseasesCalcium Metabolism DisordersCommunicable DiseasesDeficiency DiseasesDNA Virus InfectionsHerpesviridae InfectionsImmunologic Deficiency SyndromesImmune System DiseasesInfectionsMetabolic DiseasesNutrition DisordersNutritional and Metabolic DiseasesRetroviridae InfectionsRNA Virus InfectionsSexually Transmitted DiseasesSlow Virus DiseasesVirus DiseasesWater-Electrolyte ImbalanceSexually Transmitted Diseases, ViralLentivirus InfectionsMalnutritionAcquired Immunodeficiency SyndromeCytomegalovirus InfectionsHypocalcemiaMagnesium DeficiencyHIV Infections
Criteria
4 inclusion criteria required to participate
AIDS by CDC criteria
Documented CMV disease
Normal serum calcium, serum creatinine, and serum phosphate
Tolerance of foscarnet dose of 90 mg/kg bid
7 exclusion criteria prevent from participating
History of heart block
In extremis or incapacitated because of underlying illness (e.g., comatose or tracheally intubated)
Known allergy to Foscarnet
Nephrotoxic drugs such as IV pentamidine, amphotericin B, aminoglycosides, and cisplatin
Show More Criteria
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Oklahoma City Veterans Administration Med Ctr
Oklahoma City, United StatesOpen Oklahoma City Veterans Administration Med Ctr in Google MapsCompletedOne Study Center