Completed
DEHSPM for Reduction of Stool Volume and Frequency in Refractory AIDS-Related Diarrhea
What is being tested
Diethylhomospermine
Drug
Who is being recruted
Blood-Borne Infections+18
+ Urogenital Diseases
+ Genital Diseases
From 18 to 65 Years
+18 Eligibility Criteria
How is the trial designed
Treatment Study
Phase 1
Interventional
Summary
Principal SponsorVA Medical Center-Gainesville
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner
Possibly, DEHSPM will reduce stool volume and frequency in patients with refractory AIDS-related diarrhea. Patients are initially hydrated for 24 hours, followed by a 3-day baseline period. They then receive intravenous infusions of DEHSPM three times per day for 3 days, followed by observation for 3 days.
Principal SponsorVA Medical Center-Gainesville
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Treatment Study
These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Any sex
Biological sex of participants that are eligible to enroll.From 18 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Blood-Borne InfectionsUrogenital DiseasesGenital DiseasesCommunicable DiseasesImmunologic Deficiency SyndromesImmune System DiseasesInfectionsRetroviridae InfectionsRNA Virus InfectionsSexually Transmitted DiseasesSigns and SymptomsSigns and Symptoms, DigestiveSlow Virus DiseasesPathological Conditions, Signs and SymptomsVirus DiseasesSexually Transmitted Diseases, ViralLentivirus InfectionsAcquired Immunodeficiency SyndromeAIDS-Related ComplexDiarrheaHIV Infections
Criteria
3 inclusion criteria required to participate
ARC or AIDS by CDC criteria
At least 2 weeks of prior high-dose, nonspecific antidiarrheal therapy (i.e., loperamide, diphenoxylate hydrochloride-atropine sulfate, or opiates) at maximally tolerable doses
Uncontrolled diarrhea unresponsive to high-dose, nonspecific antidiarrheal therapy
15 exclusion criteria prevent from participating
Acute amoebic colitis
Acute stool-culture-positive bacterial colitis
Antibiotic therapy
Chronic pancreatitis
Show More Criteria
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Gainesville Veterans Administration Med Ctr
Gainesville, United StatesOpen Gainesville Veterans Administration Med Ctr in Google MapsCompletedOne Study Center