Completed

Retrovir (AZT) Safety and Efficacy in Asymptomatic HIV-Infected Adults

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Zidovudine

Drug
Who is being recruted

Blood-Borne Infections+15

+ Urogenital Diseases

+ Genital Diseases

Over 13 Years
+24 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
See protocol details

Summary

Principal SponsorGlaxo Wellcome
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

This study focuses on the use of Retrovir (AZT), a medication, in adult patients who are infected with HIV but do not show any symptoms of the disease. The main goal is to understand how safe and well-tolerated Retrovir is when used over a long period. This research is important as it aims to find effective treatments for HIV, helping to improve care for those living with the condition. During the study, participants receive Retrovir treatment. The study then evaluates how well the medication works in managing HIV disease. It's worth noting that the specific outcomes being measured are not listed in the provided information. However, the overall aim is to assess the safety and effectiveness of Retrovir in this particular patient group.

NCT00002048
Principal SponsorGlaxo Wellcome
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 13 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Blood-Borne InfectionsUrogenital DiseasesGenital DiseasesCommunicable DiseasesHemic and Lymphatic DiseasesImmunologic Deficiency SyndromesImmune System DiseasesInfectionsRetroviridae InfectionsRNA Virus InfectionsSexually Transmitted DiseasesSlow Virus DiseasesVirus DiseasesSexually Transmitted Diseases, ViralLentivirus InfectionsAcquired Immunodeficiency SyndromeLymphatic DiseasesHIV Infections

Criteria

4 inclusion criteria required to participate
Ability to give informed consent
HIV infection demonstrated by ELISA and confirmed by Western blot
Signs and symptoms of HIV disease limited to those characteristic of CDC groups II (asymptomatic) and III (persistent generalized lymphadenopathy - PGL)
Willingness to be followed by the originating medical center for the entire 3-year duration of the study
20 exclusion criteria prevent from participating
Active drug or alcohol abuse sufficient in the investigator's opinion to prevent compliance with the study regimen
Antiretroviral drugs or biologic response modifiers within 3 months of study entry
Any other experimental agents
Any probenecid-containing product
Show More Criteria

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 22 locations

LaJolla Veterans Administration Med Ctr

La Jolla, United StatesOpen LaJolla Veterans Administration Med Ctr in Google Maps

AIDS Clinical Trials Group

San Diego, United States

Georgetown Univ Med Ctr

Washington D.C., United States

Univ of Miami School of Medicine

Miami, United States
Completed22 Study Centers