Completed

Fluconazole Efficacy in Coccidioidal Meningitis Treatment

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What is being tested

Fluconazole

Drug
Who is being recruted

Blood-Borne Infections+21

+ Neuroinflammatory Diseases

+ Urogenital Diseases

Over 13 Years
+24 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
See protocol details

Summary

Principal SponsorPfizer
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

This study focuses on evaluating the effectiveness of a drug called fluconazole in treating a specific condition known as coccidioidal meningitis. This condition can occur in patients who have recently contracted the infection, experienced a relapse of a previous infection, or have not responded well to previous treatments. The importance of this study lies in its potential to improve the treatment approach for this condition and address the challenges associated with its management. During the study, participants receive fluconazole as part of their treatment regimen. The study then assesses the drug's efficacy, safety, and how well it is tolerated by the patients. This involves monitoring the patients' health and response to the drug. The study does not compare fluconazole with any other treatment, but rather, it aims to understand its benefits and potential risks when used for treating coccidioidal meningitis.

Principal SponsorPfizer
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 13 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Blood-Borne InfectionsNeuroinflammatory DiseasesUrogenital DiseasesGenital DiseasesBacterial Infections and MycosesCommunicable DiseasesImmunologic Deficiency SyndromesImmune System DiseasesInfectionsMycosesNervous System DiseasesOpportunistic InfectionsRetroviridae InfectionsRNA Virus InfectionsSexually Transmitted DiseasesSlow Virus DiseasesVirus DiseasesSexually Transmitted Diseases, ViralLentivirus InfectionsAcquired Immunodeficiency SyndromeCoccidioidomycosisMeningitisHIV InfectionsAIDS-Related Opportunistic Infections

Criteria

12 inclusion criteria required to participate
Allowed: Amphotericin B

Allowed: Antiviral therapy (e.g., zidovudine (AZT))

Allowed: Immunocompromised patients

Allowed: Immunosuppressive therapy including corticosteroids and/or cytotoxic agents

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12 exclusion criteria prevent from participating
Any exceptions to these prohibitions of concomitant medications must be approved by Pfizer Central Research prior to study entry

Excluded: Barbiturates

Excluded: Coumadin type anticoagulants

Excluded: Oral hypoglycemics

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Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 3 locations

Tucson Veterans Administration Med Ctr

Tucson, United StatesOpen Tucson Veterans Administration Med Ctr in Google Maps

HIV Research Group

San Diego, United States

Audie L Murphy Veterans Administration Hosp

San Antonio, United States
Completed3 Study Centers