Study of Abnormal Acquired and Genetic Coagulation Factors in Children With Porencephaly and Stroke
Data Collection
Cardiovascular Diseases+26
+ Central Nervous System Diseases
+ Brain Ischemia
Summary
Study start date: February 22, 1999
Actual date on which the first participant was enrolled.OBJECTIVES: Effective treatment and prevention strategies for childhood stroke and porencephaly can only be developed once the causes are understood. There is increasing evidence that inherited and acquired coagulation abnormalities, alone or in combination with environmental factors, predispose to arterial and venous thrombosis. Inherited abnormalities of factor V leiden, prothrombin, protein C, protein S, and antithrombin III may account for many of these thromboses. At present there is little information on the existing distribution of these coagulation anomalies in children with thrombosis. Recent reports suggest that these clotting abnormalities may be responsible for some instances of intracranial hemorrhage, porencephaly, cerebral palsy and fetal death. The objectives of this protocol are: 1) to determine the frequency of coagulation abnormalities in children with porencephaly or stroke as compared to healthy children, 2) to determine the frequency of coagulation abnormalities in children with porencephaly or stroke as compared to their family members, 3) to determine the frequency of coagulation abnormalities in mothers of children with stroke as compared to mothers of healthy children, and 4) to describe the exogenous conditions, which in concert with coagulation factors, may have led to the development of thrombosis in children with stroke. STUDY POPULATION: This study will examine: 1) children with a history of porencephaly or stroke, 2) their biological mothers, fathers, and siblings, 3) healthy volunteer children, and 4) healthy volunteer mothers. DESIGN: This is a case-control study conducted at the National Institute of Neurological Disorders and Stroke. Children with a history of porencephaly or stroke before 18 years of life, their first-degree relatives, healthy volunteer children, and healthy volunteer mothers will be enrolled. Each subject may complete a blood draw, buccal smear, questionnaire, and/or review of medical records depending on their study group. OUTCOME MEASURES: This study will measure the frequency of several coagulation factors among the study's different population groups as well as examine the exogenous conditions that may have contributed to stroke in these children. Analysis will be descriptive and quantitative.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.130 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Until 45 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
INCLUSION CRITERIA: CHILDREN WITH A HISTORY OF PORENCEPHALY OR STROKE: Children less than 18 years of age with a history of porencephaly or cerebral infarction (stroke). Children less than 18 years of age with a history of spastic hemiplegic or quadriplegic cerebral palsy (ICD-9 codes 343.1, 343.2, 343.3, 343.4, 343.8 and 343.9) with radiographic evidence of porencephaly or stroke. A diagnosis of porencephaly as defined by a fluid-filled cavity within the cerebral hemispheres which may or may not communicate with CSF spaces and confirmed by at least one imaging method including computed tomography (CT), magnetic resonance (MR) and or Doppler ultrasonography. A diagnosis of cerebral infarction (stroke) as defined by a new focal neurologic deficit lasting greater than or equal to 24 hours and presumably due to a vascular process (ICD-9 codes 430-437) and confirmed by brain imaging, either computed tomography (CT), magnetic resonance (MR) or Doppler ultrasonography. Informed consent of the parent. Informed assent of the child, when available. FIRST-DEGREE RELATIVES OF CHILDREN WITH PORENCEPHALY OR STROKE: Full biological first-degree relatives of children with a history of porencephaly or stroke enrolled in this study. Informed consent of each participant. Informed assent of each participant under 18 years, when available. HEALTHY CHILDREN: Children less than 18 years of age. Informed consent of the parent. Informed assent of the child when available. HEALTHY MOTHERS: Women between 18 and 45 years of age. History of full-term pregnancy. Informed consent of the participant. EXCLUSION CRITERIA: CHILDREN WITH A HISTORY OF PORENCEPHALY OR STROKE: Children greater than 18 years of age. Maternal history of cocaine abuse during pregnancy. History of cancer. History of other chromosomal or metabolic disorder. History of trauma and or child abuse. Isolated subdural hematomas. History of aneurysm or vascular malformations. Congenital heart disease. Sickle cell disease. History of CNS infection. HEALTHY CHILDREN: Children greater than 18 years of age. Maternal history of cocaine abuse during pregnancy. History of cancer. History of other chromosomal or metabolic disorder. History of trauma and or child abuse. Isolated subdural hematomas. History of aneurysm or vascular malformations. Congenital heart disease. Sickle cell disease. History of CNS infection. History of stroke or porencephaly. HEALTHY MOTHERS: Volunteer has biological children without a history of cancer, head trauma, aneurysm, chromosomal or metabolic disorder, congenital heart disease, sickle cell disease, meningitis or encephalitis, or stroke. Cocaine use during pregnancy.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, United StatesOpen National Institutes of Health Clinical Center, 9000 Rockville Pike in Google Maps