Efficacy of Elevated CD4 Cell Counts on CMV Retinitis
Data Collection
Blood-Borne Infections+23
+ Urogenital Diseases
+ Genital Diseases
Summary
Study start date: February 1, 1997
Actual date on which the first participant was enrolled.This is a clinical trial to determine whether elevated CD4 counts resulting from medications against human immunodeficiency virus (HIV) are effective in controlling cytomegalovirus (CMV) retinitis. Patients with non-progressive retinal disease consistent with inactive CMV retinitis in a location that is not immediately sight threatening, who are currently receiving systemic maintenance therapy with ganciclovir, foscarnet, or cidofovir, and who have a total CD4 cell count greater than 150 cells per microliter will have their anti-CMV therapy discontinued. Patients will then be closely followed for progression of their CMV retinitis. The primary endpoint of the study will be progression of CMV retinitis. Secondary endpoints will include the occurrence of extraocular CMV disease, morbidity, mortality, virologic data, and HIV burden.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.15 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
INCLUSION CRITERIA: Diagnosis of AIDS as defined by the Centers for Disease Control. Inactive, non-sight-threatening CMV retinitis. Non sight-threatening CMV retinitis is defined as CMV retinitis not within 1000 microns from the optic disc or 1000 microns from the fovea. Exception: patients with CMV retinitis within 1000 microns of the fovea or disc in only one eye, if visual acuity in that eye is worse than 20/400 without the use of eccentric fixation, and visual acuity in the other eye is 20/400 or better. CD4 T cell count greater than 150 cells per microliter. Patients must be able understand the nature of the study, agree to the provision, and understand and sign the informed consent form. Women and men age 18 or older are eligible for enrollment. Platelets greater than 25,000/microliter. Hemoglobin greater than 8.5 gms. Total neutrophil count greater than 750/mm(3). Karnofsky performance score greater than or equal to 60. Receiving systemic anti-CMV therapy. Receiving anti-HIV therapy. If the patient is receiving IL-2, at least one month from last infusion must elapse prior to assessment for eligibility. EXCLUSION CRITERIA: Intraocular sustained release ganciclovir implant in the eye for less than 9 months, or other organ involvement from CMV infection requiring use of systemic ganciclovir or foscarnet. CMV retinitis should not involve the retina solely anterior to the equator, or within 1000 microns from the optic disc, or within 1000 microns from the fovea. Exception: patients with lesions that have involved the fovea or disc and caused visual acuity worse than 20/400 without the use of eccentric fixation, may be included. Opacification of the cornea, lens, or vitreous in either eye that precludes examination of the fundus. Other retinal disease that could obscure the diagnosis of CMV retinitis, such as ocular toxoplasmosis. Significant psychiatric or emotional disorders that would impair patient understanding or participation in the trial. Life expectancy less than three months. Active CMV disease requiring systemic anti-CMV therapy. CMV retinitis first diagnosised with CD4 T-cell count greater than 150 cells per microliter. Need for medications with anti-CMV effect. Participation in conflicting clinical trial. Progression of CMV retinitis between screening and baseline examinations.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location