A Phase I Study of Continuous Intravenous Infusion of PSC 833 and Vinblastine in Patients With Metastatic Renal Cancer
PSC 833
+ vinblastine
Urogenital Diseases+12
+ Female Urogenital Diseases and Pregnancy Complications
+ Kidney Diseases
Treatment Study
Summary
Study start date: February 1, 1997
Actual date on which the first participant was enrolled.The Phase I clinical trial of the combination of 120-hour continuous intravenous infusion of vinblastine with oral PSC 833 has shown activity in patients with advanced malignancies, particularly renal cell cancer. The MTD of vinblastine in combination with the oral drink solution of PSC 833 was determined to be 0.9 mg/m2/day for five days and 12.5 mg/kg po q 12 hours for eight days, respectively. For the soft gel capsule formulation, the MTD was determined to be 0.6 mg/m2/day vinblastine for five days and 4 mg/kg po q 6 hours PSC 833 for eight days. Ataxia was the dose limiting toxicity. Of the 46 patients, two complete remissions and one partial remission were seen among 29 patients with renal cell carcinoma. In this Phase I study, patients with advanced renal carcinoma will be treated with escalating doses of vinblastine given as a 72 hour infusion, starting at approximately 40% of the total standard dose. A shorter infusion schedule of vinblastine was chosen since there is evidence in other cytotoxic combinations that PSC 833 increases the AUC and decreases the plasma clearance of chemotherapeutic agents by approximately twofold. Cytochrome P 450 3A or CYP3A, which is the major cytochrome enzyme in the metabolism of vinblastine and PSC 833, will be measured during the first and fourth cycle through an in vivo test using a single intravenous dose of midazolam, a short-acting benzodiazepine. Vinblastine and PSC 833 pharmacokinetics will be performed at the same time. For patients with accessible lesions, tumor biopsy will be requested.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.46 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
DISEASE CHARACTERISTICS: Histologically proven renal cancer with clear cell component: Measurable or evaluable disease; No brain metastases; No grade 2 or greater peripheral neuropathy or neurologic toxicity symptoms. PRIOR/CONCURRENT THERAPY: Biologic Therapy: Not specified. Chemotherapy: No prior or concurrent hypersensitivity to PSC 833 or cyclosporine A. Endocrine Therapy: Not specified. Radiotherapy: No prior radiation therapy within 4 weeks of study. Surgery: No major surgery within 4 weeks of study. Other: No concurrent treatments that interfere with cyclosporine blood concentrations. PATIENT CHARACTERISTICS: Age: 18 and over. Performance Status: ECOG 0-2. Life Expectancy: At least 16 weeks. Hematopoietic: ANC greater than or equal to 1500/mm(3); Platelet count greater than or equal to 100,000/mm(3). Hepatic: Bilirubin no greater than 1.5 x normal; AST no greater than 2.5 x normal. Renal: Creatinine no greater than 2.0 mg/dL OR; Creatinine clearance greater than or equal to 50 mL/min. Cardiovascular: No concurrent angina or myocardial infarction that has not been appropriately treated. Other: Not pregnant or nursing. Effective contraceptive required of all fertile patients. Patients with a history of curatively treated basal cell or squamous cell carcinoma are eligible. No HIV seropositivity. No chronic hepatitis or cirrhosis. Patients with concurrent reversible conditions such as diabetes, hypercalcemia, hyperuricemia, hyperviscosity, infection, renal disease, or spinal cord compression are eligible with appropriate therapy. Patients must give written informed consent.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
National Cancer Institute (NCI)
Bethesda, United StatesOpen National Cancer Institute (NCI) in Google Maps