Dehydroepiandrosterone Treatment of Mid-Life-Related Mood Disorders in Women and Men
Dehydroepiandrosterone
Behavior+3
+ Mental Disorders
+ Behavioral Symptoms
Treatment Study
Summary
Study start date: June 1, 1995
Actual date on which the first participant was enrolled.Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland in concentrations that decrease with age. In humans low DHEA levels have been associated with a variety of adverse biological consequences, including increased cardiovascular disease, decreased immune function, decreased bone density, negative lipid profile and an increased fat to muscle ratio. In this study, we investigate the effects on mood and behavior of DHEA in men and women with midlife-related mood disorders in a double-blind, placebo-controlled, crossover trial. We specifically ask whether increasing DHEA levels will mitigate any or all of the neurasthenia-like symptoms characteristic of these disorders.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.60 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
INCLUSION CRITERIA: Subjects for this study will meet the following criteria: A current episode of minor (meeting 3-4 criterion symptoms) or major depression of moderate severity or less on the SCID severity scale for depression and not meeting DSM-IV criteria symptom #9 (suicide) as determined by the administration of the minor depression module of the SADS-L and the Structured Clinical Interview for DSM-IV. Additionally, to ensure that subjects meet a minimum threshold for severity of depression, subjects will have scores greater than or equal to 10 on either the Beck Depression Inventory (BDI) or the Center for Epidemiologic Studies - Depression (CES-D) Scale during at least three of the four clinic visits during the two month screening phase. Subjects will be excluded if they meet any of the following criteria: major depression of greater than moderate severity, DSM-IV criteria #9 (suicide), or anyone requiring immediate treatment after clinical assessment, functional impairment ratings of five or six for more than seven consecutive days on daily ratings; Age 40-65; No prior hormonal therapy for the treatment of menopause/andropause-related mood or physical symptoms within the last six months; In good medical health. EXCLUSION CRITERIA: The following conditions will constitute contradictions to treatment with DHEA and will preclude a subject's participation in this protocol: Positive (threshold) response to SCID major depression section item #9, suicidal ideation; Anyone requiring immediate treatment after clinical assessment; Severity ratings greater than moderate on the SCID; Functional impairment ratings of five or six for more than seven consecutive days on daily ratings Current treatment with antidepressant medications Prostate nodules or cancer Moderate symptoms of benign prostatic hypertrophy such as hesitancy, urgency, frequent voiding and feeling of incomplete voiding History of ischemic cardiac disease Renal disease Hepatic dysfunction Women with a history of carcinoma of the breast, or any women with a family history of the following: premenopausal breast cancer or bilateral breast cancer in a first degree relative; multiple family members (greater than three relatives) with postmenopausal breast cancer Women with a history of uterine cancer Patients with a known hypersensitivity to DHEA or other androgens Pregnant women
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
National Institute of Mental Health (NIMH)
Bethesda, United StatesOpen National Institute of Mental Health (NIMH) in Google Maps