Completed

Neurological Conditions Diagnosis and Natural History Study

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Study AimThis study aims to screen and evaluate patients with neurological conditions and their family members for potential enrollment in future research studies.
What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Nervous System Disease

+ Healthy Volunteer
From 2 to 100 Years

See all eligibility criteria

How is the trial designed

Other

Utilizing specific methods not covered by standard models in order to address unique research questions.
Observational
Study Start: September 1993

See protocol details

Summary

Principal SponsorNational Institute of Neurological Disorders and Stroke (NINDS)
Last updated: October 6, 2025
Sourced from a government-validated database.Claim as a partner
Study start date: September 30, 1993Actual date on which the first participant was enrolled.

This study focuses on understanding various neurological conditions by evaluating patients and their families. It aims to identify individuals who may be eligible for future research studies. By gathering data on the natural progression of these conditions, the study hopes to improve the understanding of neurological disorders, which could lead to better care and treatment plans in the future. Additionally, the study will create a pool of healthy volunteers who could participate in other related research, helping to match them with specific study needs. Participants in this study include both individuals with neurological conditions and their family members. The study involves diagnostic evaluations to gather data, but no experimental treatments are provided. The results, such as how the conditions progress over time, are carefully recorded for research purposes. The study's doctors serve as advisors to the participants' regular healthcare providers, ensuring that the primary care continues while contributing valuable information for ongoing and future research efforts.

Official TitleDiagnosis and Natural History Protocol for Patients With Different Neurological Conditions 
Principal SponsorNational Institute of Neurological Disorders and Stroke (NINDS)
Last updated: October 6, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details
3813 patients to be enrolledTotal number of participants that the clinical trial aims to recruit.
Other
Some studies use unique or mixed approaches that don't fit standard categories. These may include innovative observational methods or studies tailored to specific research questions.

How participants are selected
Participants are selected without using randomization. They may be chosen based on convenience, access, or willingness to participate. This approach is common when random selection isn’t practical.
Another way to select participants is through a probability sample, where participants are chosen randomly, so everyone has an equal chance to be included.

How information is collected
Researchers start collecting data from the present day forward, following participants over time to observe outcomes. This approach helps identify how exposures or behaviors may lead to health events in the future.Other Ways to Collect Data
Retrospective: These studies use existing medical records or past data.
Cross-sectional: These studies collect data at one single point in time.
Others: Some studies use a mix of approaches or less common designs depending on the research goal.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria
Any sexBiological sex of participants that are eligible to enroll.
From 2 to 100 YearsRange of ages for which participants are eligible to join.
Healthy volunteers not allowedIf individuals who are healthy and do not have the condition being studied can participate.
Conditions
Pathology
Nervous System Disease
Healthy Volunteer
Criteria
No eligibility criteria are available at this time.Please check with the study contact for more details. 
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives
3 intervention groups 

are designated in this study

This study does not include a placebo group 

Treatment Groups
Group I
Family Members who are 2 years old or older of people with a neurological disorder
Group II
healthy volunteers age 18 and older
Group III
subjects with neurological disorders who are 2 years old or older
Study Objectives
Primary Objectives

The goal is to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols. No investigational treatments will be administered on this protocol and the NIH physicians will be playing a consultative role to the patient s primary physician.

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
This study has 1 location
Suspended
National Institutes of Health Clinical CenterBethesda, United StatesSee the location
CompletedOne Study Center