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Neural Systems of Cognition in Healthy Adults: fMRI, MEG and EEG Study

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Study Aim

This study aims to observe and understand the neural systems of cognition in healthy adults by using cognitive tasks and various neuroimaging techniques such as fMRI, MEG, and EEG.

What is being collected

Data Collection

Collected at a single point in time - Cross-sectional
Who is being recruted

From 18 to 65 Years
+8 Eligibility Criteria
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How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: September 1993
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Summary

Principal SponsorNational Institute of Mental Health (NIMH)
Study ContactNIMH LBC VolunteerMore contacts
Last updated: March 21, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 17, 1993

Actual date on which the first participant was enrolled.

This study aims to understand how the human brain works by combining cognitive tasks with neuroimaging techniques. It uses functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and electroencephalography (EEG) to measure brain activity in healthy individuals while they perform cognitive tasks. These tasks focus on various aspects of brain function, such as perception, attention, memory, decision-making, emotion, plasticity, and social interactions. The study is important because it helps researchers learn more about the neural systems that control these functions, which could lead to improved understanding and treatment of brain-related conditions. Normal volunteers aged 18-65 who are in good general health are invited to participate in this minimal risk study. During the study, participants perform cognitive tasks in behavioral and/or neuroimaging sessions using fMRI or MEG. The outcomes of the study are measured by combining performance on cognitive tasks with brain activity data from fMRI and MEG. This provides information about the neural processes underlying different aspects of human cognition, including visual perception, memory, learning, emotion, social cognition, decision-making, and attention. Participants will be contributing to valuable research that can enhance our understanding of the human brain and its functions.

Official TitleRegional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory
NCT00001360
Principal SponsorNational Institute of Mental Health (NIMH)
Study ContactNIMH LBC VolunteerMore contacts
Last updated: March 21, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

4100 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate
Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.

7 exclusion criteria prevent from participating
* Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.

are an NIMH employee or a relative

-have serious vision or hearing problems

-are taking prescription drugs or supplements that may affect brain function-

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

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National Institutes of Health Clinical Center

Bethesda, United StatesOpen National Institutes of Health Clinical Center in Google Maps
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One Study Center