Completed

Natural History of Metabolic Abnormalities in Children With Epilepsy

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What is being collected

Data Collection

Who is being recruted

Epileptic Syndromes+14

+ Brain Diseases

+ Central Nervous System Diseases

See all eligibility criteria
How is the trial designed

Observational
Study Start: April 1992
See protocol details

Summary

Principal SponsorNational Institute of Neurological Disorders and Stroke (NINDS)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 1, 1992

Actual date on which the first participant was enrolled.

We propose to study children with recent onset partial epilepsy, cryptogenic infantile spasms, and idiopathic Lennox-Gastaut Syndrome with serial FDG-PET to elucidate the natural history and evolution of metabolic abnormalities associated with such epilepsies. The severity of the seizure disorder, and cognitive impairment, when present, will be correlated with the presence and extent of focal and global cerebral metabolic abnormalities.

Official TitleNatural History of Metabolic Abnormalities in Children With Epilepsy
NCT00001325
Principal SponsorNational Institute of Neurological Disorders and Stroke (NINDS)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

80 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Epileptic SyndromesBrain DiseasesCentral Nervous System DiseasesEpilepsyEpilepsies, PartialEpilepsy, GeneralizedMetabolic DiseasesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesNervous System DiseasesNeurologic ManifestationsNutritional and Metabolic DiseasesSeizuresSigns and SymptomsSpasms, InfantilePathological Conditions, Signs and SymptomsGenetic Diseases, InbornLennox Gastaut Syndrome

Criteria

INCLUSION CRITERIA: Patients with partial seizures, infantile spasms and Lennox-Gastaut syndrome will be selected. EXCLUSION CRITERIA: Evidence of a structural lesion as cause for epilepsy. Degenerative or metabolic disease. Inability to comply with the protocol.

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, United StatesOpen National Institute of Neurological Disorders and Stroke (NINDS) in Google Maps
CompletedOne Study Center