Recruiting

HIV Pathogenesis in Human Blood and Body Fluids

Study Aim

This study aims to observe and collect blood and other biological samples from individuals for research on HIV and other infectious or immune deficiency diseases.

What is being collected

Data Collection

Collected from today forward - Prospective

Who is being recruted

Immune System Diseases+4

+ Infections

+ Pathologic Processes

From 18 to 120 Years

+8 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.

Observational

Study Start: March 1993

See protocol details

Summary

Principal SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Study ContactCatherine A Seamon, R.N.More contacts

Last updated: July 23, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: March 9, 1993

Actual date on which the first participant was enrolled.

We are studying virologic and/or immunologic parameters of HIV infection and other infectious or non-infectious immune deficiency diseases in order to better understand the pathogenesis of HIV. Because of the lack of an adequate animal model it is generally necessary to utilize human peripheral blood cells for studying aspects of either in vivo or in vitro HIV infection. We wish to be able to continue to elucidate many pathogenic aspects of HIV infection in relation to other infectious or non-infectious immune regulation and dysregulation using human peripheral blood mononuclear cells as a model.

NCT00001281

Principal SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Study ContactCatherine A Seamon, R.N.More contacts

Last updated: July 23, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

2419 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 120 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Immune System DiseasesInfectionsPathologic ProcessesPathological Conditions, Signs and SymptomsDisease AttributesCommunicable DiseasesImmunologic Deficiency Syndromes

Criteria

6 inclusion criteria required to participate

18 years of age or older

Adequate venous access

Be willing and able to provide written informed consent on screening, comply with study requirements and procedures, and comply with clinic policies

Have a blood pressure less than or equal to 180/100: pulse rate 50-100, unless a lower pulse rate is considered normal for the volunteer

Show More Criteria

2 exclusion criteria prevent from participating

Active substance abuse or history of prior substance abuse that may interfere with protocol compliance or compromise volunteer safety

Pregnant and/or breastfeeding females

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group

Treatment Groups

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Recruiting

National Institutes of Health Clinical Center

Bethesda, United StatesOpen National Institutes of Health Clinical Center in Google Maps

Completed

Washington Hospital Center

Washington D.C., United States

Recruiting

2 Study Centers