Recruiting

Diagnosis and Treatment of Fasting Hypoglycemia in Conditions like Insulinomas

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Study Aim

This study aims to observe how fasting hypoglycemia is diagnosed and treated in people with conditions like insulinomas, focusing on resolving low blood sugar levels.

What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Adenoma+14

+ Digestive System Diseases

+ Digestive System Neoplasms

From 18 to 120 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: May 1991
See protocol details

Summary

Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study ContactCraig S Cochran, R.N.More contacts
Last updated: July 23, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 21, 1991

Actual date on which the first participant was enrolled.

Study Description: The purpose of this study is to gain knowledge and experience in the diagnosis and therapy of patients with fasting hypoglycemia due to diverse etiologies, such as insulinomas. Study subjects will be evaluated and treated for their particular condition according to standard care. Objectives: 1. To understand the pathophysiology and various causes of hypoglycemia (e.g., insulinomas, MEN1, MEN2). 2. To identify new circulating biomarkers of insulinomas. 3. To create a repository of clinical data and samples for future research of insulinomas. Endpoints: None

NCT00001276
Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study ContactCraig S Cochran, R.N.More contacts
Last updated: July 23, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

1500 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 120 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AdenomaDigestive System DiseasesDigestive System NeoplasmsEndocrine System DiseasesEndocrine Gland NeoplasmsAdenoma, Islet CellMetabolic DiseasesNeoplasmsNeoplasms by Histologic TypeNeoplasms by SiteNeoplasms, Glandular and EpithelialNutritional and Metabolic DiseasesPancreatic DiseasesPancreatic NeoplasmsGlucose Metabolism DisordersHypoglycemiaInsulinoma

Criteria

3 inclusion criteria required to participate
Male, females ages >= 18
Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors
Patients with documented fasting blood glucose below 55 mg/dl
3 exclusion criteria prevent from participating
Medically unstable per the assessment of the PI
Patients with significant cardiac disease will be excluded
Subjects who are pregnant per self-report

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

National Institutes of Health Clinical Center

Bethesda, United StatesOpen National Institutes of Health Clinical Center in Google Maps
Recruiting
One Study Center