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Diagnosis and Treatment of Fasting Hypoglycemia in Conditions like Insulinomas

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Study AimThis study aims to observe how fasting hypoglycemia is diagnosed and treated in people with conditions like insulinomas, focusing on resolving low blood sugar levels.
What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Hypoglycemia

+ Insulinoma
From 18 to 120 Years

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How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: May 1991

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Summary

Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study ContactCraig S Cochran, R.N.
Last updated: October 7, 2025
Sourced from a government-validated database.Claim as a partner
Study start date: May 21, 1991Actual date on which the first participant was enrolled.

This study aims to improve the understanding and treatment of fasting hypoglycemia, a condition where blood sugar levels drop too low when not eating for a while. It focuses on different causes like insulinomas, which are tumors that produce insulin, and conditions such as MEN1 and MEN2. By learning more about these conditions, the study hopes to identify new biomarkers, which are indicators found in the blood, that can help diagnose insulinomas. This research could lead to better ways to diagnose and treat those with fasting hypoglycemia, ultimately improving patient care. Participants in this study are evaluated and treated according to standard medical care specific to their condition. The study does not have a specific intervention but rather observes the outcomes of the current treatment methods. Throughout the study, researchers collect clinical data and samples, creating a valuable resource for future research. The main focus is on resolving hypoglycemia, ensuring that participants achieve stable blood sugar levels. While there are no direct interventions or new treatments tested, the study's findings aim to enhance understanding and management of hypoglycemia in the long term.

Official TitleFasting Hypoglycemia: Diagnosis and Treatment 
Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study ContactCraig S Cochran, R.N.
Last updated: October 7, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details
1500 patients to be enrolledTotal number of participants that the clinical trial aims to recruit.
Cohort
These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

How participants are selected
Participants are selected without using randomization. They may be chosen based on convenience, access, or willingness to participate. This approach is common when random selection isn’t practical.
Another way to select participants is through a probability sample, where participants are chosen randomly, so everyone has an equal chance to be included.

How information is collected
Researchers start collecting data from the present day forward, following participants over time to observe outcomes. This approach helps identify how exposures or behaviors may lead to health events in the future.Other Ways to Collect Data
Retrospective: These studies use existing medical records or past data.
Cross-sectional: These studies collect data at one single point in time.
Others: Some studies use a mix of approaches or less common designs depending on the research goal.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria
Any sexBiological sex of participants that are eligible to enroll.
From 18 to 120 YearsRange of ages for which participants are eligible to join.
Healthy volunteers not allowedIf individuals who are healthy and do not have the condition being studied can participate.
Conditions
Pathology
Hypoglycemia
Insulinoma
Criteria
No eligibility criteria are available at this time.Please check with the study contact for more details. 
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives
One single intervention group 

is designated in this study

This study does not include a placebo group 

Treatment Groups
Group I
Patients with hypoglycemia due to diverse etiologies.
Study Objectives
Primary Objectives

resolution of hypoglycemia

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
This study has 1 location
Recruiting
National Institutes of Health Clinical CenterBethesda, United StatesSee the location
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One Study Center