Recruiting

Database of Normative and Adapted Movement Strategies for Human Motion

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Study Aim

This observational study aims to collect data on your gait kinematics, which includes measuring strength, spasticity, and balance, to understand normal and adapted human motion strategies.

What is being collected

Data Collection

Who is being recruted

Central Nervous System Diseases

+ Nervous System Diseases

+ Movement Disorders

From 1 Months to 99 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Case-Control

Comparing exposures between individuals with and without disease in order to identify potential risk factors.
Observational
Study Start: March 1995
See protocol details

Summary

Principal SponsorNational Institutes of Health Clinical Center (CC)
Study ContactMayra J MedranoMore contacts
Last updated: July 10, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 13, 1995

Actual date on which the first participant was enrolled.

STUDY DESCRIPTION: The purpose of this study is to develop a database of normative and adaptive control strategies for human motion. Volunteers will serve as subjects after they complete a neuromusculoskeletal screening exam. Subjects will be asked to perform one or more tasks related to the execution of activities of daily living such as: walking on the ground, walking on a treadmill, quiet and perturbed standing, stair ascent and descent, turning and jumping, and isolated upper and lower extremity limb movements or trunk movements. The subjects movement patterns will be recorded using a three-dimensional motion tracking system. Motion data will be analyzed using a rigid body six degree-of-freedom approach when applicable. Temporal/spatial, kinematic, kinetic, and surface electromyographic variables will be collected and calculated. When only temporal-spatial parameters are of interest, an instrumented portable walkway system may be used. OBJECTIVES: Primary objectives: To develop a database of normative and adapted movement strategies for human movement. The variables calculated from the established database will be presented as mean time histories to serve as standards by which individual patient and group motion data may be compared. ENDPOINTS: Primary Endpoint: The primary endpoint here is to accumulate a large database of participants with and without different neuromuscular disorders that includes multiple measures of physical function and performance, so we can begin to investigate the mechanisms underlying various disorders on either a group or individual basis.

NCT00001252
Principal SponsorNational Institutes of Health Clinical Center (CC)
Study ContactMayra J MedranoMore contacts
Last updated: July 10, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

7500 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Case-Control

These studies compare people who have a disease (cases) with those who don't (controls). The goal is to look back at previous exposures or risk factors to identify what might have contributed to the disease.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 1 Months to 99 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Central Nervous System DiseasesNervous System DiseasesMovement Disorders

Criteria

7 inclusion criteria required to participate
In good general health as evidenced by medical history or diagnosed with impairment of neuromusculoskeletal system

In the case of infants and very young children, they need to be able to imitate or perform an action on cue (e.g., reach out for a toy that is presented or take steps if placed on a treadmill) based on the parent report if the subject is a child and physician observation during history and physical examination

Adults; 18 years 99 years

Children; One month old to 17 years of age

Show More Criteria

3 exclusion criteria prevent from participating
Pregnancy

Individuals with pacemakers

Adults unable to provide informed consent

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

National Institutes of Health Clinical Center

Bethesda, United StatesOpen National Institutes of Health Clinical Center in Google Maps
Recruiting
One Study Center