Evaluation of Perimenopause-Related Mood and Behavioral Disorders in Women

This study focuses on women experiencing mood and behavioral changes related to perimenopause, a phase leading up to menopause. The main goal is to understand the role of hormonal changes in causing depression during this period. The study is important as it aims to provide clarity on a controversial topic and could improve the diagnosis and treatment of perimenopausal depression. The study seeks women who are in the perimenopause stage and will evaluate them through various methods including a psychiatric interview, medical history review, physical exam, and blood and urine tests. During the study, participants will undergo a series of evaluations. These include completing standard questionnaires like the Beck Depression Inventory, Hamilton Depression and Anxiety Scales, and the Center for Epidemiologic Studies-Depression Scale. They will also need to rate their symptoms daily and provide blood samples for hormone level checks, including neurosteroid levels. The study does not involve any treatment but aims to collect valuable data that could potentially link depression to changes in reproductive hormones during the perimenopause phase.