Recruiting

Immunological Response and Reagent Collection in Filarial Infections

Study Aim

This study aims to observe and define the factors influencing susceptibility to filarial infections, the development of filarial diseases, and the beneficial or adverse responses to chemotherapy.

What is being collected

Drug Data

Collected from today forward - Prospective

Drug

Who is being recruted

Infections+10

+ Nematode Infections

+ Skin Diseases

From 3 to 100 Years

+7 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.

Observational

Study Start: March 1991

See protocol details

Summary

Principal SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Study ContactLori A Penrod, R.N.More contacts

Last updated: July 2, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: March 15, 1991

Actual date on which the first participant was enrolled.

Patients admitted on this protocol will have, or be suspected of having, one of the filarial infections affecting humans. After routine clinical evaluation they will be studied in depth immunologically, and their blood cells and/or serum will be collected to provide reagents (eg., specific antibodies, T-cell clones, etc.) that will be used in the laboratory to address the broader questions of diagnosis, immunoregulation, pathology and immunoprophylaxis. Careful observations of the patients' clinical and immunologic responses to therapy will be made, as well as long-term follow-up of these changes. It is anticipated both that the patients will receive optimal clinical care for their infections and that the specimens collected from them will prove to be valuable reagents for the laboratory studies of the immunologic responses unique to filarial or other related helminth infections.

NCT00001230

Principal SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Study ContactLori A Penrod, R.N.More contacts

Last updated: July 2, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

500 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 3 to 100 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

InfectionsNematode InfectionsSkin DiseasesSkin Diseases, InfectiousSkin Diseases, ParasiticSecernentea InfectionsSpirurida InfectionsSkin and Connective Tissue DiseasesFilariasisHelminthiasisMansonelliasisOnchocerciasisParasitic Diseases

Criteria

4 inclusion criteria required to participate

Ability to give informed consent

Access to a primary medical care provider outside of the NIH

Age 3-100 years

Clinical evidence suggestive of a filarial infection

3 exclusion criteria prevent from participating

Although pregnant or nursing women can be enrolled, they will be excluded from receiving treatment while pregnant or breastfeeding

Any condition that the investigator feels put the subject at unacceptable risk for participation in the study

Less than 3 year of age; greater than 100 years of age

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group

Treatment Groups

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

National Institutes of Health Clinical Center

Bethesda, United StatesOpen National Institutes of Health Clinical Center in Google Maps

Recruiting

One Study Center