Completed

Comprehensive Evaluation of the Etiology and Pathogenesis of Chronic Lung Disease (Screening Protocol)

What is being collected

Data Collection

Collected from today forward - Prospective

Who is being recruted

Lung Diseases

+ Respiratory Tract Diseases

From 7 to 90 Years

See all eligibility criteria

How is the trial designed

Case-Only

Examining characteristics of individuals with a disease in order to identify genetic or environmental factors contributing to the condition.

Observational

Study Start: November 1984

See protocol details

Summary

Principal SponsorNational Heart, Lung, and Blood Institute (NHLBI)

Last updated: January 18, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: November 18, 1984

Actual date on which the first participant was enrolled.

The chronic lung diseases are those disorders associated with functional and/or structural derangement to the alveolar structures, airways, pulmonary blood vessels, pleura and/or mediastinum. The purpose of this project is to permit the comprehensive evaluation of patients referred to the Pulmonary Branch of the National Heart, Lung, and Blood Institute (NHLBI) in order to: (1) develop an understanding of the etiology and pathogenesis of these disorders; and (2) identify individuals who will be suitable candidates for other NHLBI protocols. Testing and procedures will only be performed when medically indicated for the purposes of making a diagnosis or obtaining information likely to be useful in the management of the subjects' disease or condition.

Official TitleComprehensive Evaluation of the Etiology and Pathogenesis of Chronic Lung Disease (Screening Protocol)

NCT00001183

Principal SponsorNational Heart, Lung, and Blood Institute (NHLBI)

Last updated: January 18, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

6564 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Case-only

These studies focus only on individuals who have a specific disease. Researchers examine patterns—often genetic or environmental—to uncover what might be linked to the condition.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 7 to 90 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Lung DiseasesRespiratory Tract Diseases

Criteria

* INCLUSION CRITERIA: Symptoms consistent with pulmonary disease. May have family history of lung disease. Patients with diseases of organs with known association with lung disease. Ranging in age from 7 to 90 years old. Pregnant and nursing women may participate in minimal risk procedures EXCLUSION CRITERIA: Persons with no clinical evidence of lung disease.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, United StatesSee the location

CompletedOne Study Center