Suspended

Neuroanatomy, Cerebral Metabolism, and Genetics Study in Frontotemporal Dementia and Related Brain Disorders

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Study Aim

This study aims to observe and understand the connection between brain structure, metabolism, and genetics in individuals with frontotemporal dementia and related brain disorders.

What is being collected

Data Collection

Who is being recruted

Congenital Abnormalities+15

+ Abnormalities, Multiple

+ Mental Disorders

Over 18 Years
+3 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Observational
Study Start: January 1981
See protocol details

Summary

Principal SponsorNational Institute of Neurological Disorders and Stroke (NINDS)
Last updated: December 12, 2019
Sourced from a government-validated database.Claim as a partner

Study start date: January 19, 1981

Actual date on which the first participant was enrolled.

Objective To continue the cross-sectional and longitudinal studies performed by the Cognitive Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders. Study population Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal dementia, corticobasal syndrome, and related brain disorders. Design A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function, and genetic measures in subjects with these disorders. Outcome measures MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.

NCT00001178
Principal SponsorNational Institute of Neurological Disorders and Stroke (NINDS)
Last updated: December 12, 2019
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

597 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Congenital AbnormalitiesAbnormalities, MultipleMental DisordersBrain DiseasesCentral Nervous System DiseasesIntellectual DisabilityCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesNervous System DiseasesNeurologic ManifestationsNeurodegenerative DiseasesNeurobehavioral ManifestationsNeurocognitive DisordersTauopathiesChromosome DisordersGenetic Diseases, InbornAlzheimer DiseaseDementiaDown Syndrome

Criteria

3 exclusion criteria prevent from participating
Behavioral symptoms that would preclude the gathering of data for the study
Other medical or social condition that would preclude participation in the opinion of the investigators
Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test. These women will be excluded from the imaging portions of the protocol

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, United StatesOpen National Institutes of Health Clinical Center, 9000 Rockville Pike in Google Maps
SuspendedOne Study Center