Pharmacokinetics and Bioavailability of Dideoxycytidine in Patients With Human Immunodeficiency Virus Infection
Zalcitabine
Blood-Borne Infections+14
+ Urogenital Diseases
+ Genital Diseases
Treatment Study
Summary
Laboratory tests have shown that ddC is effective in stopping the growth of the HIV in test tubes. The study will reveal the pharmacokinetic (blood levels) properties of this new drug and how long the drug remains in the body at each of six doses. This should be useful background information and should allow a simple and efficient comparative study of any new oral formulation, such as a tablet or capsule, since dose-related problems will already be known. Patients are hospitalized and receive ddC twice, once by mouth and once by IV injection. Each patient receives the drug at one of six increasing doses, and no patient is studied at more than one dose level. Following each dose, toxicity is measured before the next higher dose is given. Several blood samples and urine specimens are taken to permit measurement of the amount of drug in the bloodstream and of the speed with which it is eliminated from the body.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.12 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria Prior Medication: Allowed: Oral nonabsorbable antifungal agents. Exclusion Criteria Active drug or alcohol abuse. Co-existing Condition: Patients with fever > 102 degrees F at study entry will be excluded. Patients with fever > 102 degrees F at study entry will be excluded. Prior Medication: Excluded: Chronic systemic medications. Any other experimental drug within 2 weeks of study entry. Drugs with known nephrotoxic or hepatotoxic effects within 2 weeks of study entry. Drugs known to cause neutropenia within 2 weeks of study entry. Rifampin or rifampin derivatives, phenytoin, or barbiturates within 2 weeks of study entry. Any other medication except oral nonabsorbable antifungal agents within 72 hours of study entry. All medications, including aspirin, must be approved by investigator. All medications, including aspirin, must be approved by investigator. Patients must demonstrate the following clinical and laboratory findings: AIDS, AIDS related complex (ARC), or persistent generalized lymphadenopathy as defined by the CDC classification. No ascites. Off all medications except oral antifungal, nonabsorbable agents for 72 hours prior to study entry.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location