Study and Treatment of Post Lyme Disease (STOP-LD)
Data Collection
Vector Borne Diseases+6
+ Bacterial Infections and Mycoses
+ Bacterial Infections
Treatment Study
Summary
You will be assigned randomly (like tossing a coin) to receive either antibiotics or a placebo (sugar pill). Neither you nor your doctor will know which you are receiving. You will learn to give yourself the injection, and you will remain on your study drug for 28 days. A home health care nurse will visit you twice a week to check the injection site, and at weeks 1 and 3 the nurse will draw blood for laboratory tests. At months 1 and 6, you will be examined to see if you have fewer chronic fatigue symptoms after the antibiotics. This will include a fatigue questionnaire, a test of your mental processing speed, and a test of your cerebrospinal fluid.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.55 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: You may be eligible for this study if you: * Are between 18 and 65 years of age. * Are a resident of Long Island or greater NY metropolitan area. * Are fluent in English. * Have a history of Lyme Disease. * Have completed antibiotic treatment for Lyme Disease 6 or more months before starting the study. * Have severe fatigue. * Are not pregnant or planning to be pregnant. Exclusion Criteria: You will not be eligible for this study if you: * Have or have had major medical, neurologic, or psychiatric disorder. * Have had prior chronic pain, fatigue, or recurrent severe headaches before the onset of Lyme Disease. * Have had Fibromyalgia Syndrome. * Have a history of sleep apnea, narcolepsy, or other serious sleep disorder. * Have a learning disability. * Have had head trauma requiring hospitalization. * Have symptomatic gallbladder disease. * Are anemic. * Abuse alcohol or illicit drugs. * Have been treated with another antimicrobial agent for Lyme Disease within 6 months of study. * Need to be receiving systemic steroid therapy during drug administration and follow-up. * Have used benzodiazepines within 1 month of study entry. * Are allergic to Beta lactams (a class of antibiotics).
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location