The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient
Oxazepam
+ Zidovudine
Blood-Borne Infections+11
+ Urogenital Diseases
+ Genital Diseases
Treatment Study
Summary
Benzodiazepines (such as oxazepam) are among the most frequently prescribed class of drugs and are commonly used therapeutically for patients with chronic disease. This study is important because of the potential for toxicity resulting from a reaction between AZT and benzodiazepines and the likelihood of frequent use of the combination of these drugs in patients with HIV infection. Patients are studied to determine oral and intravenous AZT and single oral dose oxazepam pharmacokinetics. Patients then take AZT and oxazepam together to determine if interactions between the drugs occur.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.8 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria Concurrent Medication: Required: Stable prescribed dosage of zidovudine (AZT), = or > 500 mg/day. Allowed: Prophylaxis for Pneumocystis carinii pneumonia (PCP) with aerosolized pentamidine. Erythropoietin. Patients must be: HIV positive by ELISA and Western blot. Currently taking a stable prescribed dosage of 500 mg/day of zidovudine (AZT). Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: Allergy to benzodiazepines or a previously documented intolerance to zidovudine (AZT) therapy of = or < 600 mg/day. Significant underlying medical condition that could impair continuous participation in study. Malabsorption syndrome (3 or more loose stools a day for at least 4 weeks associated with an unintentional weight loss of at least 10 percent of body weight). Concurrent Medication: Excluded: Oral contraceptives. Cytotoxic chemotherapy. Ganciclovir. Flucytosine. Probenecid. Opiates. Valproic acid. Sulfa drugs. Sucralfate. Dapsone. Rifampin. Antacids within 2 hours of zidovudine (AZT) dose. Isoniazid. Ketoconazole. Pyrimethamine. Clindamycin. Aspirin. Ibuprofen. Investigational drugs not specifically allowed. Patients with the following are excluded: Allergy to benzodiazepines or a previously documented intolerance to zidovudine (AZT) therapy of = or < 600 mg/day. Significant underlying medical condition that could impair continuous participation in study. Unable to take oral medication reliably. Prior Medication: Excluded within 30 days of study entry: Antiretroviral agents other than zidovudine (AZT).
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Palo Alto Veterans Adm Med Ctr / Stanford Univ
Palo Alto, United StatesOpen Palo Alto Veterans Adm Med Ctr / Stanford Univ in Google Maps