Completed

Behavioral/Pharmacological Treatments for Alcohol-Nicotine Dependence

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What is being tested

Data Collection

Who is being recruted

Alcoholism+4

+ Behavior

+ Mental Disorders

From 18 to 50 Years
+21 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: September 1998
See protocol details

Summary

Principal SponsorThe University of Texas Health Science Center, Houston
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 1, 1998

Actual date on which the first participant was enrolled.

This study will develop a behavioral and drug relapse prevention program for individuals who are dependent on both alcohol and tobacco. The study's goal is to show that individuals receiving nicotine replacement therapy and naltrexone (Revia) with behavior therapy will have higher rates of abstinence from both smoking and drinking than individuals who do not receive the drug therapies. Individuals will be placed in a 12-week outpatient treatment program with followup assessments 1, 3, and 6 months after treatment.

Official TitleBehavioral/Pharmacological Treatments for Alcohol-Nicotine Dependence
NCT00000447
Principal SponsorThe University of Texas Health Science Center, Houston
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

200 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AlcoholismBehaviorMental DisordersSmokingSubstance-Related DisordersAlcohol-Related DisordersChemically-Induced Disorders

Criteria

9 inclusion criteria required to participate
Meets criteria for alcohol and nicotine dependence.
Individuals will be outpatients with alcohol and nicotine dependence who have completed detoxification (medicated or nonmedicated) within the past 48-120 hours.
Smoking no less than 10 cigarettes/day and no greater than 50 cigarettes/day.
Motivated to quit smoking.
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12 exclusion criteria prevent from participating
Current diagnosis of dependence on other substances except nicotine and alcohol.
Having moderately severe or severe alcohol withdrawal symptoms.
Recent (less than 48 hours) evidence of hazardous drinking (more than 2 drinks/day for females; 3 drinks/day for males).
History of opioid abuse.
Show More Criteria

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center

Houston, United StatesOpen Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center in Google Maps
CompletedOne Study Center
Behavioral/Pharmacological Treatments for Alcohol-Nicotine Dependence | PatLynk