Completed

Infusion Laboratory: Protocol 1 - Selegeline

What is being tested

Data Collection

Who is being recruted

Mental Disorders+1

+ Substance-Related Disorders

+ Cocaine-Related Disorders

From 31 to 47 Years

See all eligibility criteria

How is the trial designed

Treatment Study

Phase 1

Interventional

Study Start: November 1994

See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: November 1, 1994

Actual date on which the first participant was enrolled.

To develop a medication for the treatment of cocaine addiction using a medical human physio-neuro-psycho-immunology laboratory setting. To characterize this cocaine abusing population on a variety of psychological and physicologically measures over time from withdrawal through pere and post cocaine administration. To determine the effects of selegeline on the subjective and physiological effects of cocaine challenge in chronic crack abusers. To evaluate clinical safety issues pertaining to selegeline, to cocaine and their interaction in a chronic crack dependent population.

Official TitleInfusion Laboratory: Protocol 1 - Selegeline

NCT00000337

Principal SponsorNational Institute on Drug Abuse (NIDA)

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 31 to 47 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Mental DisordersSubstance-Related DisordersCocaine-Related DisordersChemically-Induced Disorders

Criteria

Inclusion Criteria: M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent. Exclusion Criteria: Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Friends Research Institute

Los Angeles, United StatesOpen Friends Research Institute in Google Maps

CompletedOne Study Center