Completed

Evaluation of Serotonergic System Alterations in Cocaine Addiction

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What is being tested

Data Collection

Who is being recruted

Mental Disorders+1

+ Substance-Related Disorders

+ Cocaine-Related Disorders

From 25 to 50 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1
Interventional
See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

This study focuses on understanding changes in the serotonin system in individuals who are addicted to cocaine. Serotonin is a chemical in the brain that plays a key role in mood regulation. The study aims to distinguish changes caused by cocaine use from those that existed before the addiction. This research is important as it could help improve treatment strategies for cocaine addiction by providing a clearer understanding of its impact on the brain's serotonin system. During the study, participants will be evaluated for various factors. These include craving for cocaine, changes in neuroendocrine (hormonal) function, psychological changes, and any side effects experienced. The study measures these outcomes to assess the overall impact of cocaine addiction on the serotonin system and the individual's health.

Official TitleAlterations in Serotonergic Functions in Cocaine Addicts
NCT00000312
Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

From 25 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Mental DisordersSubstance-Related DisordersCocaine-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

VA Medical Center

Brooklyn, United StatesOpen VA Medical Center in Google Maps
CompletedOne Study Center
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