Completed

Combining Behavioral Treatment With Agonist Maintenance

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What is being tested

Buprenorphine

+ methadone

Drug
Who is being recruted

Narcotic-Related Disorders+3

+ Mental Disorders

+ Opioid-Related Disorders

See all eligibility criteria
How is the trial designed

Treatment Study

Phase 3
Interventional
Study Start: February 1995
See protocol details

Summary

Principal SponsorYale University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 1995

Actual date on which the first participant was enrolled.

The purpose of this study is to evaluate whether the community reinforcement approach (CRA) plus contingency management (CM) is more effective overall than CRA only in reducing illicit opioid and cocaine use during agonist maintenance treatment and at 3 and 6 month follow-up after completion of study protocol, and to compare the efficacy of maintenance on buprenorphine to methadone when maintenance is combined with CRA only or CRA plus CM.

Official TitleCombining Behavioral Treatment With Agonist Maintenance
NCT00000311
Principal SponsorYale University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

168 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersCocaine-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

4 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Buprenorphine + CM

Group II

Experimental
Buprenorphine + VC

Group III

Experimental
Methadone + CM (contingency management)

Group IV

Experimental
methadone + VC (voucher control)

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

APT Residential Services Division

New Haven, United StatesOpen APT Residential Services Division in Google Maps
CompletedOne Study Center