Completed

Effects of Subanesthetic Concentrations of Nitrous Oxide

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What is being tested

20% N2O

+ 30% N2O

+ 40% N2O

Drug
Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

From 21 to 37 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: September 1993
See protocol details

Summary

Principal SponsorUniversity of Chicago
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 1, 1993

Actual date on which the first participant was enrolled.

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Official TitleEffects of Subanesthetic Concentrations of Nitrous Oxide
NCT00000249
Principal SponsorUniversity of Chicago
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

10 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 21 to 37 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 \& 30 minutes

Group II

Active Comparator
Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes

Group III

Active Comparator
Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Chicago, Anesthesia & Critical Care

Chicago, United StatesOpen University of Chicago, Anesthesia & Critical Care in Google Maps
CompletedOne Study Center
Effects of Subanesthetic Concentrations of Nitrous Oxide | PatLynk