Completed

Alternate-Day Buprenorphine Dosing for Improved Treatment Compliance

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What is being tested

Data Collection

Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

From 18 to 65 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: May 1997
See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 1997

Actual date on which the first participant was enrolled.

This study focuses on exploring the long-term effectiveness of alternate-day dosing schedules for buprenorphine, a medication used to treat opioid dependence. The goal is to understand if this dosing schedule can improve treatment compliance when there are no other influencing factors. The study is designed for individuals struggling with opioid dependence, aiming to provide a treatment approach that could potentially make their recovery journey more manageable. Participants in this study will receive buprenorphine following an alternate-day dosing schedule. The study measures several outcomes to evaluate the treatment's success. These include assessing drug use, opioid dependence and psychiatric status, overall treatment outcome, retention in the treatment program, and the number of weeks participants remain abstinent from opioids. The study also looks at the number of weeks participants maintain continuous abstinence.

Official TitleBuprenorphine Detoxification - BBDVI
NCT00000237
Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Treatment Research Center

Burlington, United StatesOpen Treatment Research Center in Google Maps
CompletedOne Study Center