Completed

Buprenorphine Dosing for Extended Treatment Effectiveness

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What is being tested

Data Collection

Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

This study focuses on exploring the effectiveness of a specific medication, buprenorphine, in managing opioid use. The research aims to determine if a six times daily dose of buprenorphine can lead to a longer, 120-hour dosing schedule. This study is important as it could potentially simplify treatment plans and improve the quality of life for individuals dealing with opioid dependence. During this treatment study, participants receive buprenorphine orally, six times a day. The study measures various aspects to evaluate the medication's effectiveness. These include assessing the appropriate dose, monitoring drug use, evaluating the effects of the opioid agonist, and observing any signs of opioid withdrawal. By examining these factors, the study seeks to understand the potential benefits and risks associated with this dosing schedule.

Official TitleAlternate Day Buprenorphine Administration, Phase XII
NCT00000235
Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Treatment Research Center

Burlington, United StatesOpen Treatment Research Center in Google Maps
CompletedOne Study Center