Completed

Evaluation of Alternate-Day Buprenorphine Blockade

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What is being tested

Data Collection

Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

From 30 to 49 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1
Interventional
Study Start: February 1993
See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 1993

Actual date on which the first participant was enrolled.

This study focuses on evaluating the effectiveness of a medication called buprenorphine in managing opioid dependence. The goal is to understand how well this treatment works in blocking the effects of opioids, potentially helping those struggling with opioid addiction. The study is in its early stages, known as Phase 1, and is conducted with a treatment purpose. Participants in this study will undergo a 'buprenorphine blockade challenge'. This involves taking buprenorphine and then observing various responses. These include changes in drug use, opioid withdrawal symptoms, and physical changes like blood pressure, heart rate, pupil diameter, and respiration. The study also measures buprenorphine levels in the blood and asks participants to estimate their subjective dose. This helps researchers understand the drug's characteristics and effects.

Official TitleAlternate-Day Buprenorphine. Phase V
NCT00000224
Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 30 to 49 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Treatment Research Center

Burlington, United StatesOpen Treatment Research Center in Google Maps
CompletedOne Study Center