Completed

Evaluation of Twice-Maintenance Dose Buprenorphine for 48-Hour Effects

What is being tested

Data Collection

Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

From 28 to 45 Years

See all eligibility criteria

How is the trial designed

Treatment Study

Phase 1

Interventional

Study Start: July 1992

See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 1992

Actual date on which the first participant was enrolled.

This study focuses on individuals who are on a daily maintenance dose of a medication called buprenorphine. The main goal is to find out if taking twice the usual daily dose every other day can still provide the same benefits without any changes in its effects, both positive and negative, for a full 48 hours. This research is important as it could potentially simplify the treatment process for those who require buprenorphine, making it more convenient and less frequent. During this study, participants will be given their buprenorphine dose in an alternate-day manner, meaning they will receive twice their usual dose every other day. The study will measure several outcomes to evaluate the effectiveness of this approach. These include identifying the right dose, monitoring drug use, assessing the effects of the opioid, observing any signs of opioid withdrawal, and measuring the diameter of the pupil. These measurements will help determine if alternate-day dosing is as effective and safe as daily dosing.

Official TitleAlternate-Day Buprenorphine Administration. Phase II

NCT00000222

Principal SponsorNational Institute on Drug Abuse (NIDA)

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 28 to 45 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Treatment Research Center

Burlington, United StatesOpen Treatment Research Center in Google Maps

CompletedOne Study Center