Completed

Methadone to Buprenorphine Cross-Over Treatment

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Data Collection

Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

From 21 to 50 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: February 1992
See protocol details

Summary

Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 1992

Actual date on which the first participant was enrolled.

This study aims to find methods for transitioning patients from methadone to buprenorphine. The focus is on individuals who are currently using methadone as part of their treatment. The importance of this research lies in potentially improving care for those dependent on opioids, by exploring a new treatment approach that could offer benefits over current methods. Participants in this study will follow a process to switch from methadone to buprenorphine. The effects of this transition will be measured by evaluating drug use, opiate craving, and withdrawal symptoms. These are key indicators to understand the effectiveness and safety of this new treatment approach.

Official TitleMethadone/Buprenorphine Cross-Over Study
NCT00000208
Principal SponsorNational Institute on Drug Abuse (NIDA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 21 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

4 inclusion criteria required to participate
M/F ages 21-50.
Opiate dependence according to DSM-IV criteria.
Self-reported use within the last 30 days.
Agreeable to conditions of study and signed informed consent.
6 exclusion criteria prevent from participating
Psychiatric disorder that requires medication therapy.
History of seizures.
Pregnant and/or nursing women.
Dependence on ETOH or benzodiazepines or other sedative-hynotics.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Friends Research Institute

Los Angeles, United StatesOpen Friends Research Institute in Google Maps
CompletedOne Study Center