Completed

Buprenorphine and Desipramine Treatment for Opiate and Cocaine Dependence

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What is being tested

Data Collection

Who is being recruted

Narcotic-Related Disorders+2

+ Mental Disorders

+ Opioid-Related Disorders

From 18 to 65 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: August 1988
See protocol details

Summary

Principal SponsorYale University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 1988

Actual date on which the first participant was enrolled.

This study focuses on helping individuals who are dealing with dependence on opiates and cocaine. It aims to assess the effectiveness of two medications, buprenorphine and desipramine, in managing these dependencies. The study is important as it could potentially provide a new treatment approach for those struggling with opiate and cocaine addiction, thereby improving their quality of life and overall health. During this study, participants receive either buprenorphine or desipramine as part of their treatment. The effectiveness of these medications is evaluated based on how well they help manage the participants' dependence. As with any study, there may be potential risks and benefits associated with participation, but these are carefully monitored to ensure the safety and well-being of all involved.

Official TitleBuprenorphine Maintenance for Opioid Addicts
NCT00000202
Principal SponsorYale University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Narcotic-Related DisordersMental DisordersOpioid-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Criteria

Please contact site for information.

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

VA Connecticut Healthcare System

New Haven, United StatesOpen VA Connecticut Healthcare System in Google Maps
CompletedOne Study Center