Completed

Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.

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What is being tested

Data Collection

Who is being recruted

Alzheimer Disease+11

+ Mental Disorders

+ Brain Diseases

Over 65 Years
+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Phase 3
Interventional
See protocol details

Summary

Principal SponsorNational Institute on Aging (NIA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Official TitleAlzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.
NCT00000176
Principal SponsorNational Institute on Aging (NIA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

Over 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Alzheimer DiseaseMental DisordersBrain DiseasesCentral Nervous System DiseasesDementiaMemory DisordersNervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsNeurodegenerative DiseasesNeurobehavioral ManifestationsNeurocognitive DisordersTauopathies

Criteria

1 inclusion criteria required to participate
Healthy women 65 or older with a family history of memory problems not currently on estrogen.
3 exclusion criteria prevent from participating
Significant neurological impairment
Current estrogen use
History of breast cancer

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 22 locations

Suspended

University of Alabama

Birmingham, United StatesOpen University of Alabama in Google Maps
Suspended

University of California, Irvine

Irvine, United States
Suspended

New England Center for Headache

Stamford, United States
Suspended

Howard University

Washington D.C., United States
Completed22 Study Centers