Suspended
The Effects of Sex Hormones on Cognition and Mood in Older Adults
What is being tested
Data Collection
Who is being recruted
Mental Disorders+1
+ Cognition Disorders
+ Mood Disorders
From 65 to 90 Years
+6 Eligibility Criteria
How is the trial designed
Treatment Study
Interventional
Summary
Principal SponsorNational Institute on Aging (NIA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner
Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).
Official TitleThe Effects of Sex Hormones on Cognition and Mood in Older Adults
Principal SponsorNational Institute on Aging (NIA)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Treatment Study
These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Any sex
Biological sex of participants that are eligible to enroll.From 65 to 90 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Mental DisordersCognition DisordersMood DisordersNeurocognitive Disorders
Criteria
1 inclusion criteria required to participate
Women and men aged 65-90 who have not received hormone replacement for the last three months.
5 exclusion criteria prevent from participating
Previous head injury with loss of consciousness for more than one hour.
Men with a history of prostate cancer.
Men on testosterone replacement within the past three months.
Women with a history of breast or uterine cancer.
Show More Criteria
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Suspended
SuspendedOne Study Center