Longitudinal Evaluation of Keratoconus Progression and Patient Quality of Life
Data Collection
Collected from today forward - ProspectiveCorneal Diseases
+ Eye Diseases
+ Keratoconus
Summary
Study start date: June 1, 1995
Actual date on which the first participant was enrolled.Keratoconus is a condition that affects the cornea, the clear front part of the eye. It causes the cornea to thin and bulge out, leading to distorted vision. People with keratoconus often need glasses or rigid contact lenses to see clearly, and some may even require a corneal transplant. The condition typically affects individuals during their prime earning years and significantly impacts their lives. The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study aims to better understand how this disease progresses and what factors might influence its severity. By doing so, it hopes to provide answers to common patient questions and improve the overall management of this complex eye condition. The CLEK Study is observing 1,209 patients with keratoconus over a period of 3 years. Participants undergo annual examinations at 15 different clinical centers. These check-ups include tests to measure visual acuity, assess the quality of life, capture images of the cornea, examine the fit of contact lenses, and evaluate the overall health of the eye. The study does not involve any treatment, but rather collects information to better understand the disease. The findings from this study will help eye care practitioners manage keratoconus more effectively and provide patients with a clearer understanding of what to expect from their condition.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 12 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Patients with keratoconus were eligible if they were at least 12 years old; had an irregular cornea as determined by keratometry, retinoscopy, or direct ophthalmoscopy in at least one eye; had Vogt's striae, Fleischer's ring, or corneal scarring characteristic of keratoconus in at least one eye; and planned to stay in the area for at least 3 years. They were ineligible if they had bilateral corneal transplants or bilateral nonkeratoconic eye disease (cataract, intraocular lenses, macular disease, or optic nerve disease other than glaucoma).
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 14 locations
University of California, Berkeley, School of Optometry
Berkeley, United StatesOpen University of California, Berkeley, School of Optometry in Google MapsSouthern California College of Optometry
Fullerton, United StatesJules Stein Eye Institute, University of California at Los Angeles
Los Angeles, United StatesNova Southeastern University, Health Professions Division, College of Optometry
Fort Lauderdale, United States