Monitoring Vision and Health Outcomes in Non-Arteritic Ischemic Optic Neuropathy Patients
Data Collection
Cardiovascular Diseases+4
+ Cranial Nerve Diseases
+ Eye Diseases
Summary
Study start date: October 1, 1994
Actual date on which the first participant was enrolled.Non-Arteritic Ischemic Optic Neuropathy (NAION) is a common condition that causes sudden vision loss in older adults, with no known effective treatment. It can affect both eyes in up to 40% of patients, with a significant risk within the first two years. The Ischemic Optic Neuropathy Decompression Trial (IONDT) aimed to compare the effectiveness of optic nerve decompression surgery (ONDS) with careful observation alone in patients newly diagnosed with NAION. The surgery was believed to restore vision by reducing pressure on the optic nerve. However, the study found that surgery was not better than careful observation and could potentially be harmful. This led to the abandonment of this costly and ineffective surgery for NAION treatment, leaving a lack of treatment options for the condition.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 50 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
All living patients from the 420 patients originally enrolled in the IONDT have been asked to participate in the IONDT Followup Study. No new patients are being recruited.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 24 locations
Doheny Eye Institute, University of Southern California
Los Angeles, United StatesOpen Doheny Eye Institute, University of Southern California in Google MapsJules Stein Eye Institute
Los Angeles, United StatesDepartment of Ophthalmology, University of California, San Francisco
San Francisco, United StatesDepartment of Ophthalmology, University of Florida
Gainesville, United States