Heparin-Coated Intraocular Lens for Uveitis Patients After Cataract Surgery
Data Collection
Cataract+2
+ Eye Diseases
+ Lens Diseases
Treatment Study
Summary
Study start date: March 1, 1994
Actual date on which the first participant was enrolled.This study focuses on patients with uveitis, a condition that can lead to complications after cataract surgery with intraocular lens implantation. These complications may include iris adhesions to the lens, cellular deposits on the lens surface obscuring vision, and uveitis itself. The study aims to investigate the safety and effectiveness of a heparin-coated intraocular lens, which may offer a more compatible surface and potentially reduce post-surgery complications. This research is crucial as it could pave the way for improved care and reduced risks for uveitis patients undergoing cataract surgery. In this study, 80 patients with a history of uveitis who require cataract surgery will be randomly assigned to receive either a heparin-coated intraocular lens or an unmodified lens. The primary goal is to evaluate the development of cellular deposits on the lens surface one year after surgery. These deposits will be assessed using standard photographs by a masked grader. Secondary goals include measuring visual acuity, intraocular inflammation, the development of anterior and posterior synechiae, and corneal endothelial cell counts.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Conditions
Pathology
Criteria
Women and men 18 years or older with a documented history of uveitis in an eye requiring cataract surgery are eligible for the study. In all patients, the eye must be free of active inflammation for at least 3 months before surgery, with or without anti-inflammatory medications. Exclusion criteria include corneal pathology or hazy media that preclude evaluation of the intraocular lens, uncontrolled glaucoma, and diabetes mellitus. Monocular patients and patients who cannot be followed for at least 1 year are also excluded.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
National Institutes of Health
Bethesda, United StatesOpen National Institutes of Health in Google Maps