Suspended

Whole Body Hyperthermia for Rheumatoid Diseases Treatment

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What is being tested

Data Collection

Who is being recruted

Connective Tissue Diseases+1

+ Musculoskeletal Diseases

+ Rheumatic Diseases

From 18 to 65 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
See protocol details

Summary

Principal SponsorNational Center for Research Resources (NCRR)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

This study focuses on using whole body hyperthermia (WBH), a non-toxic heating system, to treat rheumatoid diseases. The system, previously used at the University of Wisconsin, heats patients to a specific temperature for a set time. Researchers believe this could help with rheumatoid diseases, as it has been shown to trigger the production of certain proteins, known as soluble tumor necrosis factor-receptors (sTNF-R) I and II. These proteins could potentially improve conditions for patients with active rheumatoid arthritis, making this study significant in exploring new treatment options for these diseases. The study aims to help those with active rheumatoid arthritis, a condition that currently lacks a definitive cure. During the study, participants undergo the WBH treatment, which involves heating their bodies to 41.8 degrees Celsius for 60 minutes. The study evaluates how this treatment affects various biological markers, including cytokine levels, TNF levels, sTNF-R levels, and changes in cellular TNF receptors. The goal is to see if these changes could lead to remission in patients with active rheumatoid arthritis. The study also considers potential risks and benefits associated with the WBH treatment.

Official Title41.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid Diseases
NCT00000106
Principal SponsorNational Center for Research Resources (NCRR)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Connective Tissue DiseasesMusculoskeletal DiseasesRheumatic DiseasesSkin and Connective Tissue Diseases

Criteria

8 inclusion criteria required to participate
Patients are required to meet the criteria of the American College of Rheumatology (ACR)for rheumatoid arthritis.
Patients should be in functional class II, or III according to the criteria of the ACR.
All candidates must be unsuccessfully treated (lack of efficacy) with at least two of the following disease-modifying antirheumatic drugs: hydroxychloroquinine, oral or injectable gold, methotrexate, azathioprine, penicillamine, and sulfasalazine.
Patients receiving nonsteroidal antiinflammatory drugs (NSAIDs), corticosteroids (<= 10 mg per day), or both are eligible if the dosage has been stable for at least four weeks before treatment and remained so throughout the study and follow-up period (the use of narcotics for pain flares is allowed).
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Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

K4/666 CSC 600 Highland Av

Madison, United StatesOpen K4/666 CSC 600 Highland Av in Google Maps
SuspendedOne Study Center