Completed

Effects of Lead Overburden on Neuropsychological Development in Inner City Children

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What is being collected

Data Collection

Who is being recruted

Heavy Metal Poisoning+1

+ Lead Poisoning

+ Poisoning

1 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Defined Population

Following a specific population over time in order to understand disease trends and health outcomes within that group.
Observational
See protocol details

Summary

Principal SponsorNational Center for Research Resources (NCRR)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Inner city children face a higher risk of lead overburden, which can impact their cognitive abilities. This study focuses on understanding the neuropsychological effects of lead overburden and how it influences the development of attention and memory at different ages. The research is part of a broader study that aims to comprehend the impact of lead overburden on children's attention and memory development. This study holds significance as it could shed light on the specific ways lead overburden affects children's cognitive development, helping to address this challenge effectively. During the study, participants will undergo Event-Related Potential (ERP) measures of attention and memory. These tests involve watching various computer images while wearing scalp electrodes that record from 11 sites. The tests will be conducted every eight months, for a total of three sessions. The study will include 30 children with lead overburden, selected from the larger study, and they will be matched with 30 children without lead overburden. This part of the study aims to provide a physiological functioning index to be used alongside behavior-based measures of attention and memory, offering valuable insights into the different measures.

Official TitleDoes Lead Burden Alter Neuropsychological Development?
NCT00000104
Principal SponsorNational Center for Research Resources (NCRR)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Defined Population

Researchers follow a specific group of people—such as residents of a region or members of an organization—over time. The goal is to track disease patterns and health outcomes in a defined setting.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Heavy Metal PoisoningLead PoisoningPoisoningChemically-Induced Disorders

Criteria

1 inclusion criteria required to participate
Pregnant mothers of the Phillips neighborhood in Minneapolis, Minnesota. Subject recruitment will take place in local clinics which serve pregnant women and offspring

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Department of Neurology 420 Delaware St. SE, Box 486 Mayo

Minneapolis, United StatesOpen Department of Neurology 420 Delaware St. SE, Box 486 Mayo in Google Maps
CompletedOne Study Center