Epigenetic Regulation of Excercise Induced Asthma

Date de début de l'étude : 1 août 2021

For EIA patients Inclusion Criteria: * written agreement * age \>=12 and \<= 24 * known exercise induced asthma * Group 1: skin prick test positiv house-dust allergy, eNO \> 30 ppb, MCT PD20 \< 0,1 mg * Group 2: skin prick test negative house-dust allergy, eNO \< 20 ppb, MCT PD20 \< 1 mg * lung function before ECC forced vital capacity (FVC) ≥ 75% and forced exspiratory pressure in one second (FEV1) ≥ 70% Exclusion Criteria: * age \< 12 und \> 24 years * lung function FVC \< 75% und FEV1\< 70% * inability to understand the range of the study * chronic asthma with systemic cortisone therapy * regular therapy with inhalative corticosteroids or leukotriene-antagonists \<14 days before visit 1 * intake of long acting beta-agonists (LABA) 48 h before examination * intake of short acting beta-agonists (SABA) 8 h before examination * acute severe infection (pneumonia) within the last 4 weeks * other chronic diseases or infections (HIV, Tbc) * pregnancy For healthy controls Inclusion Criteria: * written agreement * age \>=18 and \<= 24 Exclusion Criteria: * age \< 18 and \> 24 years * known asthma bronchiale or other chronic lung diseases * lung function FVC \< 90% and FEV1 \< 80% * allergic sensitization in skin prick test * eNO \> 30 ppb * inability to understand the range of the study * acute severe infection (pneumonia) within the last 4 weeks * other chronic diseases or infections (HIV, Tbc) * pregnancy