Supplémentation en vitamines D3 et K2 pour la minéralisation osseuse chez les patients atteints de diabète de type 2

This study focuses on individuals with Type 2 diabetes, a condition marked by high blood sugar levels, which is a leading cause of death. People with Type 2 diabetes often face related health issues, such as bone demineralization, which can lead to a decrease in bone density. This bone weakening could be linked to the levels of Non-carboxylated Osteocalcin and Insulin, two molecules that play a role in bone mineralization. The study aims to address this issue as many people do not get enough vitamins, specifically Vitamins D3 and K, in their daily diet. These vitamins are important for maintaining bone health. The study proposes to give these vitamins as supplements to patients with Type 2 diabetes to prevent a decrease in bone density and potentially improve their health outcomes. Participants in the study are from the Western part of the country and undergo a comprehensive clinical evaluation, including a detailed medical history. They are then randomly assigned to one of three groups. The first group receives Vitamin D3 and a placebo, the second group receives Vitamin K2 and a placebo, and the third group receives both Vitamin D3 and K2. Blood samples are collected and the levels of Non-carboxylated Osteocalcin and Insulin are measured before and after the supplementation. The study also measures cholesterol and triglyceride levels, and calculates the HOMA index for insulin resistance. Participants are asked to keep a daily record of their vitamin intake and any adverse reactions. The results of the study are shared with each participant at the end of the study.