BulleEchoLung Ultrasound Characterization of Bullous Emphysema
Collecte de données
Données recueillies dès le début de l'étude - ProspectiveMaladie chronique+6
+ Maladies pulmonaires obstructives
+ Maladies pulmonaires
Cas témoins
Analyse de profils avec et sans la maladie pour comprendre ce qui pourrait l'avoir favorisée.Résumé
Date de début de l'étude : 26 juin 2019
Date à laquelle le premier participant a commencé l'étude.Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease affecting a growing number of adults in the world which is responsible for a large public health burden through heavy morbidity and mortality. Emphysema is one of a wide spectrum of pulmonary complications linked to COPD, defined as the abnormal permanent enlargement of the airspaces distal to the terminal bronchioles accompanied by destruction of the alveolar wall. Disease progression is correlated to worsening and enlargement of emphysema lesions, sometimes conflating in sizeable bullae, deleterious to normal mechanical pulmonary function. Bullous emphysema (BE) is sometimes eligible to invasive curative treatment through surgery or interventional bronchoscopy. Diagnosis of BE relies on computerized tomodensitometry (CT), the gold-standard for evaluating pulmonary parenchyma. However, CT is not always available, and bullous emphysema can present as pneumothorax on chest radiography. The practice of lung ultrasound is currently growing in respiratory medicine and emergency departments owing to an increasing amount of evidence showcasing its reliability as a diagnostic tool, most notably for pneumothorax and other pleural diseases. Despite BE having been reported to present similarly to pneumothorax in ultrasound, its characteristics have not yet been precisely described. The primary aim of this study is to describe BE using lung ultrasound. Participants with known BE on CT will undergo a simple ultrasound examination. The secondary aim is to compare the characteristics of BE to those of pneumothorax using lung ultrasound. To achieve this, a second group of participants with currently treated pneumothorax will also undergo lung ultrasound.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.35 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Cas témoins
Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Tout sexe
Le sexe biologique des participants éligibles à s'inscrire.À partir de 18 ans
Tranche d'âge des participants éligibles à participer.Volontaires sains non autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
Inclusion Criteria: * Bullous emphysema group * Consultation or scheduled hospitalization in a Pulmonary Medicine department * Past medical history of emphysema on computerized tomodensitometry dating less than two years * Bullous emphysema with subpleural contact of two or more intercostal spaces on tomodensitometry * Pneumothorax group * Hospitalized in a Pulmonary Medicine department for the treatment of a pneumothorax * Patent pneumothorax visible on chest x-ray dating less than 24 hours Exclusion Criteria: * Bullous emphysema group * Current pneumothorax * Past medical history of pleurodesis or pleural thickening homolateral to the bullous emphysema * All patients * Organ failure (hemodynamic, neurological, respiratory) * Recent thoracic surgery dating less than 7 days with subcutaneous emphysema * Minor participant or otherwise deprived of their freedom or their ability to consent freely * No affiliation to social security
Plan de l'étude
Découvrez tous les traitements administrés dans cette étude, leur description détaillée et ce qu'ils impliquent.Objectifs de l'étude
Objectifs principaux
Objectifs secondaires
Centres d'étude
Ce sont les hôpitaux, cliniques ou centres de recherche où l'essai est conduit. Vous pouvez trouver le site le plus proche de vous ainsi que son statut.Cette étude comporte 1 site
Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital
Rouen, FranceOuvrir Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital dans Google Maps