Effet des édulcorants non nutritifs sur la glycémie, l'insuline et le GLP-1 chez les sujets diabétiques de type 2

This study focuses on individuals with type 2 diabetes. The main goal is to compare the effects of non-nutritive sweeteners, specifically sucralose and stevia, on appetite, blood sugar levels, insulin, and a hormone called GLP-1. The study is important as it may provide insights into how these sweeteners affect diabetes management and potentially improve care for those living with this condition. During the study, participants are asked to maintain their usual diet and avoid strenuous exercise and alcohol for 24 hours before each evaluation. They attend the study center after an 8-hour fast and consume either water, water with sucralose, or water with stevia. After consuming the drink, they eat a standardized meal. Blood samples are taken at various intervals to measure blood sugar, insulin, and GLP-1 levels. Participants also complete questionnaires about their appetite and taste perception every 30 minutes. The study measures the glycemic response in blood as the primary outcome, which is the change in blood sugar levels over time after consuming the drink and meal.