Impact de la Fisétine sur la Fonctionnalité des Cellules Souches et l'Inflammation dans la Maladie Rénale Chronique Avancée

This study focuses on individuals with advanced chronic kidney disease, particularly those with diabetic kidney disease. It aims to understand the impact of a drug called fisetin on kidney function, inflammation, and physical function. Fisetin is a substance that may improve the function of certain stem cells in the body, potentially helping to reduce inflammation and improve kidney health. This research is important as it could lead to new treatments for chronic kidney disease, a condition that currently has limited treatment options. Participants in this study will receive either fisetin or a placebo (a substance with no active medication) for two days. They will be randomly assigned to receive either the study drug or the placebo. Over the course of 12 months, participants will have blood, urine, and skin and fat samples taken from the abdominal wall. They will also undergo tests to measure physical strength at certain times. The study's main goals are to examine the effect of fisetin (compared to the placebo) on inflammation and on the function of stem cells. These effects will be measured at the start of the study and again after 14 days.