END-AFLDLow Dose Colchicine for Reduced Atrial Fibrillation After Open Heart Surgery

Atrial Fibrillation (AF) is a heart condition that can occur after heart surgery, leading to increased risks and complications. Previous studies have used a drug called Colchicine to reduce the occurrence of AF, but the results were not promising due to unpleasant side effects, particularly diarrhea. However, a recent analysis suggested that a lower dose of Colchicine might reduce AF without causing severe side effects. This study aims to test this hypothesis in patients undergoing heart surgery, with the goal of improving care and reducing complications associated with AF. Participants in this study will be randomly assigned to receive either Colchicine or a placebo (a pill with no active ingredients). The Colchicine treatment will start the day before surgery and continue until hospital discharge. The main goal is to measure the occurrence of AF through an Electrocardiogram (EKG), a test that records the heart's electrical activity. The study will also monitor any side effects, particularly those related to the digestive system, to ensure the safety of the lower dose of Colchicine.