Étude d'association pangénomique pour identifier les gènes de susceptibilité à l'obésité chez les adultes obèses métaboliquement sains
GWAS
+ GWAS
Poids Corporel+5
+ Troubles de la Nutrition
+ Maladies nutritionnelles et métaboliques
Étude diagnostique
Résumé
Date de début de l'étude : 1 mai 2009
Date à laquelle le premier participant a commencé l'étude.Between 60%-70% of the risk of obesity appears to be heritable. Unfortunately, the exact genes involved have been difficult to identify. New technologies now exist to help researchers discover obesity susceptibility genes. One of these technologies is the Affymetrix Genome-Wide Human SNP (single nucleotide polymorphism) Array 6.0 chips. SNPs are individual base pair differences in genes of different individuals, and they are the main source of human genetic diversity. The "chips" are thumbnail-size silicon surfaces that contain copies of hundreds of thousands of SNPs of the human genome (in this case around 900,000). SNP chips allow researchers to screen thousands of genes in a single experiment and compare genes of subjects with a particular disease or condition with unaffected control subjects. The investigators study utilizes SNP chips to compare the genetic profiles of obese subjects (N = 20, body mass index > 35 kg/m2) without common obesity-related co-morbidities such as diabetes mellitus or hypertension with well matched, lean controls (N = 20, body mass index 18-25 kg/m2). This is a pilot study intended to explore the following: 1) possible associations between obesity and previously unidentified obesity susceptibility genes; 2) associations between known obesity genes and obesity risk in subjects without obesity-related metabolic co-morbidities; and 3) how well our genetic data conform to other studies in similar populations as a way of assessing if the investigators have identified a representative cohort of obese subjects.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.81 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Diagnostic
Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Tout sexe
Le sexe biologique des participants éligibles à s'inscrire.De 40 à 80 ans
Tranche d'âge des participants éligibles à participer.Volontaires sains autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
Inclusion Criteria: - Adults 40 year old or older Caucasian males or females BMI ≥ 35 kg/m² or history of BMI ≥ 35 kg/m², or BMi less than 25 kg/m2 No current or past use of glucose lowering drugs No current or past medical history of diabetes mellitus No current or past medical history of established coronary artery disease (angina, myocardial infraction, abnormal cardiac stress test) No current or past medical history of or treatment for thyroid disorders No current or past use of lipid lowering drugs or diagnosis of a lipid disorder No current or past medical history of or treatment for hypertension Subject's willingness to provide the study investigators with a copy of their medical records or give permission to the study investigators to access the following specific medical information: Fasting plasma glucose (less than 100 mg/dL/5.6 mmol/L) HDL-C cholesterol (more than 40 mg/dL /1.03 mmol/L) Total cholesterol (less than 239 mg/dL/ 6.18mmol/L) LDL cholesterol (less than 159 mg/dL/4.11 mmol/L) Exclusion Criteria: - Known monogenic forms of obesity Polycystic ovary disease (in women) Malabsorptive or maldigestive syndromes (Celiac disease, Crohn's Disease, inflammatory bowel disease, etc.) Anorexia nervosa or bulimia
Plan de l'étude
Découvrez tous les traitements administrés dans cette étude, leur description détaillée et ce qu'ils impliquent.2 groupes d'intervention sont désignés dans cette étude
50% de chances d'être dans le groupe placebo en aveugle
Groupes de traitement
Groupe I
ExpérimentalGroupe II
PlaceboObjectifs de l'étude
Objectifs principaux