Supplémentation en Resvératrol pour une Sensibilité à l'Insuline Améliorée dans le Diabète de Type 2

Date de début de l'étude : 1 mai 2012

Inclusion Criteria: * Male sex * Age: 40-70 years * Body fat percentage \> 25, BMI 27-35 kg/m2 * Diagnosed with type 2 diabetes at least one year before the start of the study * Well-controlled type 2 diabetics: HBA1C \< 8.0% * Oral glucose lowering medication (metformin only or in combination with sulfonylurea agents) * Sedentary * Not more than 2 hours of sports a week * No active job that requires strenuous physical activity * Stable dietary habits * Willingness to abstain from resveratrol-containing food products Exclusion Criteria: * Unstable body weight (weight gain or loss \> 3kg in the last three months) * Total body fat percentage \< 25% * Hemoglobin \< 7.8 mmol/l * Use of anticoagulants * Engagement in programmed exercise \> 2 hours total per week * Impaired kidney and/or hepatic function Creatinine 50-100 umol/L Liver enzymes, within 2 times of normal range of laboratory standard (ASAT \< 60 U/L, ALAT \< 70 U/L, Billi \<40 umol/L, gamma-GT \< 80 U/L) * No diabetes related co-morbidities like cardiovascular diseases, diabetic foot, polyneuropathy, retinopathy * Insulin dependent Diabetic subjects * Any medical condition except type 2 diabetes mellitus requiring treatment and/or medication use except metformin only or in combination with sulfonylurea agents * Intake of dietary supplements except multivitamins and minerals * Current alcohol consumption \> 20 grams/day * Subjects who don't want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study. * Participation in another biomedical study within 1 month before the first screening visit * Any contraindication to MRI scanning. These contra-indications include patients with following devices: * Central nervous system aneurysm clip * Implanted neural stimulator * Implanted cardiac pacemaker of defibrillator * Cochlear implant * Insulin pump * Or metal containing corpora aliena in the eye or brains