Utility of Isoproterenol Challenge Test to Detect Disease in Patients With Incomplete Diagnostic Criteria for Arrhythmogenic Right Ventricular Cardiomyopathy
Collecte de données
Anomalies Congénitales+4
+ Maladies Cardiovasculaires
+ Maladies Cardiaques
Résumé
Date de début de l'étude : 1 mai 2004
Date à laquelle le premier participant a commencé l'étude.Arrhythmogenic right ventricular cardiomyopathy (ARVC) formerly referred to as arrhythmogenic right ventricular dysplasia (ARVD) is a familial hetergenous clinical and molecular disease characterized by dilatation and dysfunction of the right ventricle and ventricular arrhythmias. The ventricular arrhythmias are heart rate and catecholamine dependent. Not infrequently, there is involvement of the left ventricle. The diagnosis of ARVC is critical as therapy including implantable defibrillators may prevent sudden death. However, identification of affected family members remains a major challenge due to limitation of current imaging and diagnostic techniques. We propose (1) to establish the sensitivity and specificity of the isoproterenol challenge test for ARVC by testing both patients with known ARVC and healthy volunteers; (2) to estimate the proportion of family members who present with incomplete criteria for ARVC but are subsequently diagnosed with the condition by an isoproterenol challenge test; and, (3) to study the inheritance of ARVC and the potential role of occult infection in its development.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.160 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Tout sexe
Le sexe biologique des participants éligibles à s'inscrire.Volontaires sains autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
INCLUSION CRITERIA: Patients with ARVC: Either gender, aged greater than 5 years. The presence of two major criteria; one major and two minor criteria; or four minor criteria from separate diagnostic categories. Normal Volunteers: Age and gender matched with ARVC patients, age greater than 18 years. No known cardiac disease. Normal EKG, normal echocardiogram, normal Bruce protocol treadmill exercise test. Family Members of Patients with ARVC: Either gender, aged greater than 5 years. A proband with ARVC EXCLUSION CRITERIA: Patients with ARVC: Pregnancy or lactation excludes tests with potential risk, e.g. radiation, isoprenaline, MRI, but does not exclude 12-lead ECG and echocardiogram. Coronary artery disease. Known infiltrate or congenital heart disease that could mimic the appearances of ARVC. Asthma prevents participation in Isoproterenol infusion. Any other condition that would prevent participation in the study. Normal Volunteers: Pregnancy or lactation. Asthma. Coronary artery disease, hypertension, diabetes, hypertrophic cardiomyopathy, or other known cardiomyopathy. Known infiltrative or congenital heart disease that could mimic the appearances of ARVC. Any Acute or chronic illness. Chronic drug therapy. Family Members of Patients with ARVC: Pregnancy or lactation excludes tests with potential risk, e.g. radiation, isoprenaline, MRI, but does not exclude 12-lead ECG and echocardiogram. Coronary artery disease. Known infiltrative or congenital heart disease that could mimic the appearances of ARVC. Asthma prevents participation in Isoproterenol infusion. Any other condition that would prevent participation in the study.
Centres d'étude
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